Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sanchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakumara K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF (2023) NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nat. Commun Dez 19, 2023. doi: 10.1038/s41467-023-44033-0

Ramos S, Kamps J, Pezzotti S, Winklhofer KF, Tatzelt J, Havenith M. (2023) Hydration make a difference! How to tune protein complexes between liquid-liquid and liquid-solid phase separation. Phys Chem Chem Phys 2023 Oct 16. doi: 10.1039/d3cp03299

Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, Tatzelt J, Cali T, Winklhofer KF. (2022) LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. EMBO J. 18: e112006.
doi: 10.15252/embj.2022112006
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Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M. (2021) Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies. Sci Adv. 26;7(48):eabj1826. doi: 10.1126/sciadv.abj1826

Oliva R, Mukherjee SK, Ostermeier L, Pazurek LA, Kriegler S, Bader V, Prumbaum D, Raunser S, Winklhofer KF, Tatzelt J, Winter RHA. (2021) Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III. Chemistry - A Europ. J. 16;27(46):11845-11851. doi: 10.1002/chem.202101592

Polido SA, Kamps J, Tatzelt J. (2021) Biological Functions of the Intrinsically Disordered N-Terminal Domain of the Prion Protein: A Possible Role of Liquid-Liquid Phase Separation. Biomolecules 12;11(8):1201. doi: 10.3390/biom11081201                                               

Jung S, Bader V, Natriashvili A, Koch HG, Winklhofer KF, Tatzelt J. (2020) SecY-mediated quality control prevents the translocation of non-gated porins. Sci Rep. 1: 10(1): 16347. doi: 10.1038/s41598-020-73185-y

Mohammadi B, Linsenmeier L, Shafiq M, Puig B, Galliciotti G, Giudici C, Willem M, Eden T, Koch-Nolte F, Lin YH, Tatzelt J, Glatzel M, Altmeppen HC. (2020) Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation. Mol Neurobiol. 57(6): 2812-2829. doi: 10.1007/s12035-020-01917-2

Meschede J, Sadic M, Furthmann N, Miedema T, Sehr DA, Muller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF. (2020) The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. Sci Signal: 13. doi: 10.1126/scisignal.aav1256

van Well EM, Bader V, Patra M, Sanchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trumbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF. (2019) A protein quality control pathway regulated by linear ubiquitination. EMBO J: 38(9). doi: 10.15252/embj.2018100730

Puig B, Altmeppen HC, Linsenmeier L, Chakroun K, Wegwitz F, Piontek UK, Tatzelt J, Bate C, Magnus T, Glatzel M. (2019) GPI-anchor signal sequence influences PrP^C sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice. PLoS Pathog 15: e1007520. doi: 10.1371/journal.ppat.1007520

Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R, Hassdenteufel S. (2019) The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating. Biol Open 8. doi: 10.1242/bio.040691

Salvesen O, Tatzelt J, Tranulis MA. (2019) The prion protein in neuroimmune crosstalk. Neurochem Int. Nov; 130:104335. doi: 10.1016/j.neuint.2018.11.010

Ulbrich S, Janning P, Seidel R, Matschke J, Gonsberg A, Jung S, Glatzel M, Engelhard M, Winklhofer KF, Tatzelt J. (2018) Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrP^C) in Alzheimer's disease. PLoS One 13(5): e0197659. doi: 10.1371/jppurnal.pone.0197659

Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J. (2018) Dimerization of the cellular prion protein inhibits propagation of scrapie prions. J Biol Chem 293(21): 8020-8031.
doi: 10.1074/jbc.RA117.000990

Linsenmeier L, Mohammadi B, Wetzel S, Puig B, Jackson WS, Hartmann A, Uchiyama K, Sakaguchi S, Endres K, Tatzelt J, Saftig P, Glatzel M, Altmeppen HC. (2018) Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein. Mol Neurodegener 13(1): 18. doi: 10.1186/s13024-018-0248-6

Jung S and Tatzelt J. (2018) Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases. Prion 12(2): 88-92. doi: 10.1080/19336896.2018.1435936

Eigenbrod S, Frick P, Bertsch U, Mitteregger-Kretzschmar G, Mielke J, Maringer M, Piening N, Hepp, Daude N, Windl O, Levin J, Giese A, Sakthivelu V, Tatzelt J, Kretzschmar H, Westaway D. (2017) Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice. PLoS One 12(12): e0188989. doi: 10.1371/journal.pone.0188989

Gonsberg A, Jung S, Ulbrich S, Origi A, Ziska A, Baier M, Koch HG, Zimmermann R, Winklhofer KF, Tatzelt J. (2017) The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins. J Biol Chem. 292(52): 21383-21396. doi: 10.1074/jbc.M117.788067

Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. (2017) The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife 6 doi: 10.7554/eLife.23473

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A. (2017) The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 486(3): 738-743. doi: 10.1016/j.bbrc.2017.03.112

Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU and Hipp MS. (2016) Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science 351(6269): 173-176. doi: 10.1126/science.aad2033

Puig B, Altmeppen HC, Ulbrich S, Linsenmeier L, Krasemann S, Chakroun K, Acevedo-Morantes CY, Wille H, Tatzelt J, Glatzel M. (2016) Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice. Sci Rep 6:24970. doi: 10.1038/srep24970

Bakkebø MK, Mouillet-Richard S, Espenes A, Goldmann W, Tatzelt J and Tranulis MA. (2015) The cellular prion protein: a player in immunological quiescence. Front. Immunol 6: 450. doi: 10.3389/fimmu.2015.00450

Meka DP, Müller-Rischart AK, Nidadavolu P, Mohammadi B, Motori E, Ponna SK, Aboutalebi H, Bassal M, Annamneedi A, Finckh B, Miesbauer M, Rotermund N, Lohr C, Tatzelt J, Winklhofer KF and Kramer ER. (2015) Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest 125(5): 1873-1885. doi: 10.1172/JCI79300

Dirndorfer D, Seidel RP, Nimrod G, Miesbauer M, Ben-Tal N, Engelhard M, Zimmermann R, Winklhofer KF and Tatzelt J. (2013) The alpha-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum. J Biol Chem 288(20): 13961-13973. doi: 10.1074/jbc.M112.430264

Pfeifer NV, Dirndorfer D, Lang S, Resenberger UK, Restelli MR, Hemion C, Miesbauer M, Frank A, Neutzner A, Zimmermann R, Winklhofer KF and Tatzelt J. (2013) Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria. EMBO J 32(7): 1036-1051. doi: 10.1038/emboj.2013.46

Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Augustin R, Deinlein A, Schweimer C, Kuhn PH, Lichtentaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J and Winklhofer KF. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell 49(5): 908-921. doi: 10.1016/j.molcel.2013.01.036

McCarthy JM, Franke M, Resenberger UK, Waldron S, Simpson JC, Tatzelt J, Appelhans D and Rogers MS. (2013) Anti-prion drug mPPIg5 inhibits Prp^C conversation to Prp^Sc. PLoS One 8(1): e55282. doi: 10.1371/journal.pone.0055282

McCarthy JM, Appelhans D, Tatzelt J and Rogers MS. (2013) Nanomedicine for prion disease treatment: new insights into the role of dendrimers. Prion 7(3): 198-202. doi: 10.4161/pri.24431

Kretzschmar H and Tatzelt J. (2013) Prion disease: A tale of folds and strains. Brain Pathol 23(3): 321-332. doi: 10.1111/bpa.12045

Resenberger UK, Muller V, Munter LM Baier M, Multhaup G, Wilson MR, Winklhofer KF and Tatzelt J. (2012) The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β. J Biol Chem 287(52): 43765-43776. doi: 10.1074/jbc.M112.389007

Lang S, Benedix J, Fedeles SV, Schorr S, Schirra c, Schäuble N, Jalal C, Greiner M, Haßenteufel S, Tatzelt J, Kreutzer B, Edelman L, Krause E, Rettig J, Somlo S, Zimmermann R and Dudek J. (2012) Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci 125(8): 1958-1969. doi: 10.1242/jcs.096727

Resenberger UK, Winklhofer KF and Tatzelt J. (2012) Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta. Neurodegener Dis 10(1-4): 298-300. doi: 10.1159/000332596

Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF and Tatzelt J. (2011) The cellular prion protein mediates neurotoxic signaling of β-sheet-rich conformers independent of prion replication. EMBO J 30(10): 2057-2070. doi: 10.1038/emboj.2011.86

Sakthivelu V, Seidel RP, Winklhofer KF and Tatzelt J. (2011) Conserved stress-protective activity between Prion Protein and Shadoo. J Biol Chem 286(11): 8901-8908. doi: 10.1074/jbc.M110.185470

Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park D, Wurst W, Kilberg MS, Tatzelt J and Winklhofer KF. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ 18(5): 769-782. doi: 10.1038/cdd.2010.142

Karpuj MV, Gelibter-Niv S, Tiran A, Rambold A, Tatzelt J, Nunziante M and Schatzl HM. (2011) Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligonucleotides. J Biol Chem 286(9): 6911-6917.
doi: 10.1074/jbc.M110.194662

Resenberger UK, Winklhofer KF and Tatzelt J. (2011) Neuroprotective and neurotoxic signaling by the prion protein. Top Curr Chem 305: 101-119. doi: 10.1007/128_2011_160

Chu NK, Olschewski D, Seidel R, Winklhofer KF, Tatzelt J, Engelhard M and Becker CFW. (2010) Protein Immobilization on Liposomes and Lipid Coated Nanoparticles by Protein Trans Splicing. J Pept Sci 16(10): 582-588. doi: 10.1002/psc.1227

Fett ME, Pilsl A, Paquet D, Haass C, Tatzelt J, Schmid B and Winklhofer KF. (2010) Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS One 5(7): e11783. doi: 10.1371/journal.pone.0011783

Ullrich S, Muench A, Neumann S, Kremmer E, Tatzelt J and Lichtenthaler SF. (2010) The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression and secretion of the amyloid precursor protein. J Biol Chem 285(27): 20664-20674.
doi: 10.1074/jbc.M109.055608

Schumacher MC, Resenberger U, Seidel RP, Becker CFW, Winklhofer KF, Oesterhelt D, Tatzelt J and Engelhard M. (2010) Synthesis of a GPI anchor module suitable for protein posttranslational modification. Biopolymers 94(4): 457-464. doi: 10.1002/bip.21380

Miesbauer M, Pfeiffer NV, Rambold AS, Muller V, Kiachopoulos S, Winklhofer KF and Tatzelt J. (2009) Alpha-helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum. J Biol Chem 284(36): 24384-24393. doi: 10.1074/jbc.M109.023135

Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Laemmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C and Winklhofer KF. (2009) Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation. J. Biol Chem 284(34): 22938-22951. doi: 10.1074/jbc.M109.035774

Rambold AS, Miesbauer M, Olschewski D, Riemer C, Seidel R, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Becker CFW, Engelhard M, Baier M, Winklhofer KF and Tatzelt J. (2008) Green tea extracts interfere with the stress-protective activity of PrP^C and the formation of PrP^Sc. J Neurochem 107(1): 218-229. doi: 10.1111/j.1471-4159.2008.05611.x

Rambold AS, Müller V, Ron U, Ben-Tal N, Winklhofer KF and Tatzelt J. (2008) Stress-protective signaling of prion protein is corrupted by scrapie-prions. EMBO J 27(14): 1974-1984. doi: 10.1038/emboj.2008.122

Schlehe JS, Lutz AK, Pilsl A, Lämmermann K, Grgur K, Henn IH, Tatzelt J and Winklhofer KF. (2008) Aberrant folding of pathogenic parkin mutants: aggregation versus degradation. J Biol Chem 283(20): 13771-13779. doi: 10.1074/jbc.M707494200

Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth D, Yehiely F, Korth C, Moore DJ, Tatzelt J, Rubenstein E, Boucheix C, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Sisodia SS, Moskovitz J, Epstein CJ, Dawson Cruz TC, Kuziel WA, Maeda N, Sap J, Hsiao Ashe K, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE and Prusiner SB. (2008) A search for auxiliary proteins in prion replication. J Gen Virol 89(7): 1777-1788. doi: 10.1099/vir.0.2008/001255-0

Wegmann S, Miesbauer M, Winklhofer KF, Tatzelt J and Muller DJ. (2008) Observing fibrillar assemblies on scrapie-infected cells. Pflugers Arch 456(1): 83-93. doi: 10.1007/s00424-007-0433-x

Winklhofer KF, Tatzelt J and Haass C. (2008) The two faces of protein misfolding: Gain and loss of function in neurodegenerative diseases. EMBO J 27(2): 336-349. doi: 10.1038/sj.emboj.7601930

Olschewski D, Seidel R, Miesbauer M, Rambold AS, Oesterhelt D, Winklhofer KF, Tatzelt J, Engelhard M and Becker CFW. (2007) Semisynthetic murine Prion protein equipped with a GPI anchor mimic incorporates into cellular membranes. Chem Biol 14(9): 994-1006.
doi: 10.1016/j.chembiol.2007.08.007

Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J and Winklhofer KF. (2007) Parkin mediates neuroprotection through activation of IKK/NF-kB signaling. J Neurosci 27(8): 1868-1878.
doi: 10.1523/JNEUROSCI.5537-06.2007

Tatzelt J and Schatzl HM. (2007) Molecular basis of cerebral neurodegeneration in prion diseases. FEBS J 274(3): 606-611. doi: 10.1111/j.1742-4658.2007.05633.x

Rambold AS, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer KF and Tatzelt J. (2006) Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell 17(8): 3356-3368. doi: 10.1091/mbc.e06-01-0083

Hirschberger T, Storck M, Schropp B, Winklhofer KF, Tatzelt J and Tavan P. (2006) Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations. Biophys J 90(11): 3908-3918. doi: 10.1529/biophysj.105.075341

Miesbauer M, Bamme T, Riemer C, Oidtmann B, Winklhofer KF, Baier M and Tatzelt J. (2006) Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor. Biochem Biophys Res Commun 341(1): 218-224.
doi: 10.1016/j.bbrc.2005.12.168

Winklhofer KF and Tatzelt J. (2006) The role of chaperones in Parkinson's disease and prion diseases. In Handbook of Experimental Pharmacology, "Molecular chaperones in health and diseases", M Gaestel, ed. (Springer-Verlag) Vol. 172: 221-258. doi: 10.1007/3-540-29717-0_10

Bertsch U, Winklhofer KF, Hirschberger T, Bieschke J, Weber P, Hartl FU, Tavan P, Tatzelt J, Kretzschmar HA and Giese A. (2005) Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (SIFT). J Virol 79(12): 7785-7791. doi: 10.1128/JVI.79.12.7785-7791.2005

Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF and Haass C. (2005) A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. J Biol Chem 280(7): 5137-5140. doi: 10.1074/jbc.C400560200

Dumpitak C, Beekes M, Weinmann N, Metzger S, Winklhofer KF, Tatzelt J and Riesner D. (2005) The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose. Biol Chem 386(11): 1149-1155. doi: 10.1515/BC.2005.131

Henn IH, Gostner JM, Tatzelt J and Winklhofer KF. (2005) Pathogenic mutations inactivate parkin by distinct mechanisms. J Neurochem 92(1): 114-122. doi: 10.1111/j.1471-4159.2004.02854.x

Kiachopoulos S, Bracher A, Winklhofer KF and Tatzelt J. (2005) Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor. J Biol Chem 280(10): 9320-9329. doi: 10.1074/jbc.M412525200

Leffers KW, Schell J, Jansen K, Lucassen R, Kaimann T, Nagel-Steger L, Tatzelt J and Riesner D. (2004) The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites. J Mol Biol 344(3): 839-853. doi: 10.1016/j.jmb.20004.09.071

Kiachopoulos S, Heske J, Tatzelt J and Winklhofer KF. (2004) Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation. Traffic 5(6): 426-436. doi: 10.1111/j.1398-9219.2004.00185.x

Heske J, Heller U, Winklhofer KF and Tatzelt J. (2004) The C-terminal domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum. J Biol Chem 279(7): 5435-5443. doi: 10.1074/jbc.M309570200

Tatzelt J and Winklhofer KF. (2004) Folding and misfolding of the prion protein in the secretory pathway. Amyloid 11(3): 162-172. doi: 10.1080/1350-6120400000723

Winklhofer KF, Henn IH, Hay-Jackson P, Heller U and Tatzelt J. (2003) Inactivation of parkin by oxidative stress and C-terminal truncations; a protective role of molecular chaperones. J. Biol Chem 278(47): 47199-47208. doi: 10.1074/jbc.M306769200

Heller U, Winklhofer KF, Heske J, Reintjes A and Tatzelt J. (2003) Post-translational import of the prion protein into the endoplasmic reticulum interferes with cellular viability: a critical role for the putative transmembrane domain. J Biol Chem 278(38): 36139-36147.
doi: 10.1074/jbc.M304002200

Winklhofer KF, Heller U, Reintjes A and Tatzelt J. (2003) Inhibition of complex glycosylation increases formation of PrP^Sc. Traffic 4: 313-322. doi: 10.1034/j.1600-0854.2003.00088.x

Winklhofer KF, Heske J, Heller U, Reintjes A, Muranji W, Moarefi I and Tatzelt J. (2003) Determinants of the in vivo-folding of the prion protein. A bipartite function of helix 1 in folding and aggregation. J Biol Chem 278(17): 14961-14970. doi: 10.1074/jbc.M209942200

Winklhofer KF, Hartl FU and Tatzelt J. (2001) A sensitive filter retention assay for the detection of PrP^Sc and the screening of anti-prion compounds. FEBS Lett 503(1): 41-45. doi: 10.1016/s0014-5793(01)02692-8

Winklhofer KF, Reintjes A, Hoener MC, Voellmy R and Tatzelt J. (2001) Geldanamycin restores a defective heat shock response in vivo. J Biol Chem 276(48): 45160-45167. doi: 10.1074/jbc.M104873200

Gilch S, Winklhofer KF, Nunziante M, Lucassen R, Spielhaupter C, Muranyi W, Groschup MH, Riesner D, Tatzelt J and Schätzl HM. (2001) Intracellular re-outing of prion protein prevents propagation of PrP^Sc and delays onset of prion diseases. EMBO J 20(15): 3957-3966. doi: 10.1093/emboj/20.15.3957